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Experiments confirmed that the amino acid sequence LKKTET was responsible for angiogenesis, since mutagenesis of the motif severely decreased the efficiency of T4 in forming vessels

Another complication is that the biological processes thymosin beta 4 seems to promote, such as new blood vessel growth and cell migration, dont just occur in bone or muscle healing

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This pro-osteogenic effect operates through the cAMP/CREB signaling pathway